CALR

CALR
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3POW, 2CLR, 3DOW, 3POS
Dynodwyr
Cyfenwau	CALR, CRT, HEL-S-99n, RO, SSA, cC1qR, calreticulin
Dynodwyr allanol	OMIM: 109091 HomoloGene: 37911 GeneCards: CALR
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • protein folding chaperone activity; • carbohydrate binding; • hormone binding; • metal ion binding; • complement component C1q complex binding; • mRNA binding; • iron ion binding; • unfolded protein binding; • zinc ion binding; • integrin binding; • DNA binding; • chaperone binding; • peptide binding; • androgen receptor binding; • ubiquitin protein ligase binding; • RNA binding; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • endoplasmic reticulum lumen; • bilen; • focal adhesion; • extracellular region; • perinuclear region of cytoplasm; • sarcoplasmic reticulum lumen; • cnewyllyn cell; • endocytic vesicle lumen; • cell surface; • Reticwlwm endoplasmig; • extracellular exosome; • Golgi apparatus; • intracellular membrane-bounded organelle; • GO:0005578 extracellular matrix; • intracellular anatomical structure; • integral component of lumenal side of endoplasmic reticulum membrane; • sarcoplasmic reticulum; • smooth endoplasmic reticulum; • MHC class I peptide loading complex; • acrosomal vesicle; • external side of plasma membrane; • polysome; • phagocytic vesicle membrane; • endoplasmic reticulum-Golgi intermediate compartment membrane; • extracellular space; • nuclear envelope; • GO:0009327 protein-containing complex; • endoplasmic reticulum quality control compartment; • collagen-containing extracellular matrix;
Prosesau biolegol	• negative regulation of neuron differentiation; • protein folding in endoplasmic reticulum; • receptor-mediated endocytosis; • response to organic substance; • cellular senescence; • spermatogenesis; • positive regulation of dendritic cell chemotaxis; • regulation of apoptotic process; • cellular response to organic substance; • positive regulation of phagocytosis; • negative regulation of intracellular steroid hormone receptor signaling pathway; • GO:0009373 regulation of transcription, DNA-templated; • negative regulation of retinoic acid receptor signaling pathway; • cardiac muscle cell differentiation; • regulation of meiotic nuclear division; • protein maturation by protein folding; • positive regulation of cell cycle; • protein export from nucleus; • cellular response to lithium ion; • peptide antigen assembly with MHC class I protein complex; • antigen processing and presentation of peptide antigen via MHC class I; • protein stabilization; • cellular calcium ion homeostasis; • GO:1901227 negative regulation of transcription by RNA polymerase II; • positive regulation of DNA replication; • protein folding; • GO:0045996 negative regulation of transcription, DNA-templated; • GO:0033109 cortical actin cytoskeleton organization; • chaperone-mediated protein folding; • response to estradiol; • response to testosterone; • ATF6-mediated unfolded protein response; • positive regulation of substrate adhesion-dependent cell spreading; • sequestering of calcium ion; • GO:1901313 positive regulation of gene expression; • positive regulation of cell population proliferation; • protein localization to nucleus; • glucocorticoid receptor signaling pathway; • positive regulation of NIK/NF-kappaB signaling; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; • negative regulation of translation; • vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane; • positive regulation of endothelial cell migration; • negative regulation of trophoblast cell migration;
	Sources:Amigo / QuickGO
Orthologau
	811
	n/a
	ENSG00000179218
	n/a
	P27797
	n/a
	NM_004343
	n/a
	NP_004334
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CALR yw CALR a elwir hefyd yn Calreticulin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.13.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CALR.

RO
CRT
SSA
cC1qR
HEL-S-99n

Llyfryddiaeth

"Calreticulin Is Involved in Invasion of Human Extravillous Trophoblasts Through Functional Regulation of Integrin β1. ". Endocrinology. 2017. PMID 28938427.
"Somatic mutations of calreticulin in myeloproliferative neoplasms. ". Int J Hematol. 2017. PMID 28470469.
"Mannan-binding lectin, a serum collectin, suppresses T-cell proliferation viadirect interaction with cell surface calreticulin and inhibition of proximal T-cell receptor signaling. ". FASEB J. 2017. PMID 28209773.
"Progenitor genotyping reveals a complex clonal architecture in a subset of CALR-mutated myeloproliferative neoplasms. ". Br J Haematol. 2017. PMID 28168700.
"JAK2, MPL, and CALR mutations in Chinese Han patients with essential thrombocythemia.". Hematology. 2017. PMID 27875935.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CALR - Cronfa NCBI

[1]

[2]