Cellular senescence has been widely recognised for decades as a stable arrest of cell proliferation. A recent study identifies senescence establishment and maintenance as a dynamic and reversible process regulated by (in)activation of a predetermined enhancer landscape controlled by the pioneer transcription factor AP-1.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
EZH2 inhibition sensitizes retinoic acid-driven senescence in synovial sarcoma
Cell Death & Disease Open Access 16 November 2024
-
Therapeutic aspects of cell signaling and communication in Duchenne muscular dystrophy
Cellular and Molecular Life Sciences Open Access 07 April 2021
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Mayran, A. & Drouin, J. J. Biol. Chem. 293, 13795–13804 (2018).
Martínez-Zamudio, R. I. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-020-0529-5 (2020).
Hernandez-Segura, A., Nehme, J. & Demaria, M. Trends Cell Biol. 28, 436–453 (2018).
Yang, N. & Sen, P. Aging (Albany N.Y.) 10, 3590–3609 (2018).
Tasdemir, N. et al. Cancer Discov. 6, 612–629 (2016).
Sen, P. et al. Mol. Cell 73, 684–698.e8 (2019).
Eferl, R. & Wagner, E. F. Nat. Rev. Cancer 3, 859–868 (2003).
Coppé, J.-P., Desprez, P.-Y., Krtolica, A. & Campisi, J. Annu. Rev. Pathol. 5, 99–118 (2010).
Demaria, M. et al. Cancer Discov. 7, 165–176 (2017).
Baker, D. J. et al. Nature 530, 184–189 (2016).
Lee, S. & Schmitt, C. A. Nat. Cell Biol. 21, 94–101 (2019).
Ocampo, A. et al. Cell 167, 1719–1733.e12 (2016).
Wang, L. et al. Cell Reports 21, 773–783 (2017).
Sun, Y., Coppé, J.-P. & Lam, E. W.-F. Trends Mol. Med. 24, 871–885 (2018).
Ye, N., Ding, Y., Wild, C., Shen, Q. & Zhou, J. J. Med. Chem. 57, 6930–6948 (2014).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Zumerle, S., Alimonti, A. In and out from senescence. Nat Cell Biol 22, 753–754 (2020). https://doi.org/10.1038/s41556-020-0540-x
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-020-0540-x
This article is cited by
-
EZH2 inhibition sensitizes retinoic acid-driven senescence in synovial sarcoma
Cell Death & Disease (2024)
-
Therapeutic aspects of cell signaling and communication in Duchenne muscular dystrophy
Cellular and Molecular Life Sciences (2021)
