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Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors

Nature volume 386, pages 239–246 (1997)Cite this article

Abstract

GABA (γ-amino-butyric acid), the principal inhibitory neurotransmitter in the brain, signals through ionotropic (GABAA/GABAC) and metabotropic (GABAB) receptor systems. Here we report the cloning of GABAB receptors. Photoaffinity labelling experiments suggest that the cloned receptors correspond to two highly conserved GABAB receptor forms present in the vertebrate nervous system. The cloned receptors negatively couple to adenylyl cyclase and show sequence similarity to the metabotropic receptors for the excitatory neurotransmitter L-glutamate.

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Authors and Affiliations

  1. Novartis Pharma Inc., Research Department, Therapeutic Area Nervous System, CH-4002, Basel, Switzerland

    Klemens Kaupmann, Katharina Huggel, Jakob Heid, Peter J. Flor, Serge Bischoff, Stuart J. Mickel, Gary McMaster, Christof Angst, Helmut Bittiger, Wolfgang Froestl & Bernhard Bettler

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  1. Klemens Kaupmann
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Kaupmann, K., Huggel, K., Heid, J. et al. Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors. Nature 386, 239–246 (1997). https://doi.org/10.1038/386239a0

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