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SLC22A4 and RUNX1: identification of RA susceptible genes

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Abstract

Recently we reported that SLC22A4 and RUNX1 are associated with rheumatoid arthritis (RA). SLC22A4 is an organic cation transporter with unknown physiological function, and RUNX1 is a hematological transcriptional regulator that has been shown to be responsible for acute myelogenic leukemia. It is suggested that the association of RUNX1 with RA is due to its regulation of expression of SLC22A4. Because the physiological function of SLC22A4 is still unclear, further investigation is needed into how SLC22A4 affects RA susceptibility. Although the association of RUNX1 with RA was identified as a regulatory factor of SLC22A4, it is possible that RUNX1 is a key molecule in autoimmunity, as it has been reported to be associated with systemic lupus erythematosus and psoriasis, two other autoimmune diseases.

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Abbreviations

CBF :

Core-binding factor

IL :

Interleukin

IRF :

Interferon regulatory factor

LD :

Linkage disequilibrium

NCF :

Neutrophil cytosolic factor

OCT :

Organic cation transporter

PADI :

Peptidylarginine deiminase

RA :

Rheumatoid arthritis

SLE :

Systemic lupus erythematosus

SNP :

Single nucleotide polymorphism

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Authors and Affiliations

  1. Laboratory for Rheumatic Diseases, SNP Research Center, Institute of Physical and Chemical Research, 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Kanagawa, Japan

    Ryo Yamada, Shinya Tokuhiro, Xiotian Chang & Kazuhiko Yamamoto

Authors
  1. Ryo Yamada
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  2. Shinya Tokuhiro
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  3. Xiotian Chang
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  4. Kazuhiko Yamamoto
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Correspondence to Ryo Yamada.

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Yamada, R., Tokuhiro, S., Chang, X. et al. SLC22A4 and RUNX1: identification of RA susceptible genes. J Mol Med 82, 558–564 (2004). https://doi.org/10.1007/s00109-004-0547-y

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  • DOI: https://doi.org/10.1007/s00109-004-0547-y

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