CALR

Protein sy'n cael ei godio yn y corff dynol gan y genyn CALR yw CALR a elwir hefyd yn Calreticulin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.13.

CALR
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3POW, 2CLR, 3DOW, 3POS
Dynodwyr
Cyfenwau	CALR, CRT, HEL-S-99n, RO, SSA, cC1qR, calreticulin
Dynodwyr allanol	OMIM: 109091 HomoloGene: 37911 GeneCards: CALR
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • protein folding chaperone activity • carbohydrate binding • hormone binding • metal ion binding • complement component C1q complex binding • mRNA binding • iron ion binding • unfolded protein binding • zinc ion binding • integrin binding • DNA binding • chaperone binding • peptide binding • androgen receptor binding • ubiquitin protein ligase binding • RNA binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • cytosol • endoplasmic reticulum lumen • bilen • focal adhesion • extracellular region • perinuclear region of cytoplasm • sarcoplasmic reticulum lumen • cnewyllyn cell • endocytic vesicle lumen • cell surface • Reticwlwm endoplasmig • extracellular exosome • Golgi apparatus • intracellular membrane-bounded organelle • GO:0005578 extracellular matrix • intracellular anatomical structure • integral component of lumenal side of endoplasmic reticulum membrane • sarcoplasmic reticulum • smooth endoplasmic reticulum • MHC class I peptide loading complex • acrosomal vesicle • external side of plasma membrane • polysome • phagocytic vesicle membrane • endoplasmic reticulum-Golgi intermediate compartment membrane • extracellular space • nuclear envelope • GO:0009327 protein-containing complex • endoplasmic reticulum quality control compartment • collagen-containing extracellular matrix Prosesau biolegol • negative regulation of neuron differentiation • protein folding in endoplasmic reticulum • receptor-mediated endocytosis • response to organic substance • cellular senescence • spermatogenesis • positive regulation of dendritic cell chemotaxis • regulation of apoptotic process • cellular response to organic substance • positive regulation of phagocytosis • negative regulation of intracellular steroid hormone receptor signaling pathway • GO:0009373 regulation of transcription, DNA-templated • negative regulation of retinoic acid receptor signaling pathway • cardiac muscle cell differentiation • regulation of meiotic nuclear division • protein maturation by protein folding • positive regulation of cell cycle • protein export from nucleus • cellular response to lithium ion • peptide antigen assembly with MHC class I protein complex • antigen processing and presentation of peptide antigen via MHC class I • protein stabilization • cellular calcium ion homeostasis • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of DNA replication • protein folding • GO:0045996 negative regulation of transcription, DNA-templated • GO:0033109 cortical actin cytoskeleton organization • chaperone-mediated protein folding • response to estradiol • response to testosterone • ATF6-mediated unfolded protein response • positive regulation of substrate adhesion-dependent cell spreading • sequestering of calcium ion • GO:1901313 positive regulation of gene expression • positive regulation of cell population proliferation • protein localization to nucleus • glucocorticoid receptor signaling pathway • positive regulation of NIK/NF-kappaB signaling • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • negative regulation of translation • vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane • positive regulation of endothelial cell migration • negative regulation of trophoblast cell migration Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	811	n/a
Ensembl	ENSG00000179218	n/a
UniProt	P27797	n/a
RefSeq (mRNA)	NM_004343	n/a
RefSeq (protein)	NP_004334	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CALR.

• RO
• CRT
• SSA
• cC1qR
• HEL-S-99n

Llyfryddiaeth

• "Calreticulin Is Involved in Invasion of Human Extravillous Trophoblasts Through Functional Regulation of Integrin β1. ". Endocrinology. 2017. PMID 28938427.
• "Somatic mutations of calreticulin in myeloproliferative neoplasms. ". Int J Hematol. 2017. PMID 28470469.
• "Mannan-binding lectin, a serum collectin, suppresses T-cell proliferation viadirect interaction with cell surface calreticulin and inhibition of proximal T-cell receptor signaling. ". FASEB J. 2017. PMID 28209773.
• "Progenitor genotyping reveals a complex clonal architecture in a subset of CALR-mutated myeloproliferative neoplasms. ". Br J Haematol. 2017. PMID 28168700.
• "JAK2, MPL, and CALR mutations in Chinese Han patients with essential thrombocythemia.". Hematology. 2017. PMID 27875935.