AmiGO 2: Term Details for "metalloendopeptidase activity" (GO:0004222)

Term Information

Accession: GO:0004222
Name: metalloendopeptidase activity
Ontology: molecular_function
Synonyms: metalloendoprotease activity, metalloendoproteinase activity
Alternate IDs: None
Definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. Source: https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, GOC:mah
Comment: None
History: See term history for GO:0004222 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to metalloendopeptidase activity (excluding "regulates").; Link to all direct and indirect annotations to metalloendopeptidase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for metalloendopeptidase activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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Additional internal viewing options

GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0140096 catalytic activity, acting on a protein
GO:0016787 hydrolase activity
GO:0008233 peptidase activity
GO:0004175 endopeptidase activity
GO:0008237 metallopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:0017087 mitochondrial processing peptidase complex
GO:1904684 negative regulation of metalloendopeptidase activity
GO:1904685 positive regulation of metalloendopeptidase activity
GO:1904683 regulation of metalloendopeptidase activity

Parents of metalloendopeptidase activity (GO:0004222)

subject	relation	object
metalloendopeptidase activity	is_a	metallopeptidase activity (GO:0008237)
metalloendopeptidase activity	is_a	endopeptidase activity (GO:0004175)

Children of metalloendopeptidase activity (GO:0004222)

subject	relation	object
negative regulation of metalloendopeptidase activity (GO:1904684)	RO:0002212	metalloendopeptidase activity
regulation of metalloendopeptidase activity (GO:1904683)	RO:0002211	metalloendopeptidase activity
metalloendopeptidase inhibitor activity (GO:0008191)	RO:0002630	metalloendopeptidase activity
metalloendopeptidase activity involved in amyloid precursor protein catabolic process (GO:1902945)	is_a	metalloendopeptidase activity
mitochondrial processing peptidase complex (GO:0017087)	RO:0002215	metalloendopeptidase activity
positive regulation of metalloendopeptidase activity (GO:1904685)	RO:0002213	metalloendopeptidase activity

EC: 3.4.24.65; 3.4.24.69; 3.4.24.61; 3.4.24.64; 3.4.24.55; 3.4.24.57; 3.4.24.56; 3.4.24.59; 3.4.24.35; 3.4.24.34; 3.4.24.37; 3.4.24.22; 3.4.24.21; 3.4.24.24; 3.4.24.23; 3.4.24.11; 3.4.24.7; 3.4.24.14; 3.4.24.17; 3.4.24.-; 3.4.24.3; 3.4.24.19; 3.4.24.18; 3.4.24.71; 3.4.24.70; 3.4.24.72
MetaCyc: 3.4.24.55-RXN; 3.4.24.14-RXN; 3.4.24.57-RXN; 3.4.24.59-RXN; 3.4.24.18-RXN; 3.4.24.72-RXN; 3.4.24.70-RXN; 3.4.24.35-RXN; 3.4.24.37-RXN; 3.4.24.61-RXN; 3.4.24.22-RXN; 3.4.24.69-RXN; 3.4.24.24-RXN; 3.4.24.56-RXN; 3.4.24.11-RXN; 3.4.24.17-RXN; 3.4.24.19-RXN; 3.4.24.71-RXN; 3.4.24.21-RXN; 3.4.24.64-RXN; 3.4.24.23-RXN
Reactome: R-HSA-5250606; R-HSA-2533944; R-HSA-8874201; R-HSA-8876868; R-HSA-2002428; R-HSA-5250962; R-HSA-1458433; R-HSA-1474196; R-HSA-2533950; R-HSA-2168046; R-HSA-194796; R-HSA-3791295; R-HSA-177946; R-HSA-2534248; R-HSA-1564184; R-HSA-2534240; R-HSA-194793; R-HSA-3791319; R-HSA-9840532; R-HSA-194818; R-HSA-1564179; R-HSA-2022141; R-HSA-2473594; R-HSA-2473596; R-HSA-2484882; R-HSA-9840408; R-HSA-5362793; R-HSA-3791149; R-HSA-194809; R-HSA-194808; R-HSA-1474210; R-HSA-2473584; R-HSA-8867344; R-HSA-1564169; R-HSA-3791155; R-HSA-1474213; R-HSA-1564164; R-HSA-6784620; R-HSA-2485148; R-HSA-5250892; R-HSA-8943959; R-HSA-1299476; R-HSA-381435; R-HSA-8949668; R-HSA-264758; R-HSA-1251992; R-HSA-420818; R-HSA-194800; R-HSA-1299478; R-HSA-8940959; R-HSA-8940554; R-HSA-1454822; R-HSA-1564143; R-HSA-8940561; R-HSA-5228578; R-HSA-2533874; R-HSA-5333671; R-HSA-9822532; R-HSA-8949659; R-HSA-181567; R-HSA-1564142; R-HSA-1655851; R-HSA-5694082; R-HSA-2514831; R-HSA-381537; R-HSA-8949649; R-HSA-1168777; R-HSA-2179402; R-HSA-1592310; R-HSA-8874122; R-HSA-2514790; R-HSA-3828025; R-HSA-3788075; R-HSA-3371385; R-HSA-9840564; R-HSA-381518; R-HSA-4086205; R-HSA-8874194; R-HSA-2533970; R-HSA-9624272; R-HSA-8874195; R-HSA-4224014; R-HSA-2168982; R-HSA-8877620; R-HSA-8874192; R-HSA-1564120; R-HSA-2537499; R-HSA-5250978; R-HSA-1454757; R-HSA-8940641; R-HSA-8942302; R-HSA-1564112; R-HSA-9844241; R-HSA-2002440; R-HSA-8874187; R-HSA-2485111; R-HSA-3827958; R-HSA-2533965; R-HSA-9824402; R-HSA-1564117