Zepbound sulfur burps: Why they happen and how to get relief

What are sulfur burps?

Sulfur burps, sometimes called “eggy burps,” get their name from the smell of hydrogen sulfide (H2S) gas. This gas is produced in the digestive system when certain foods are broken down by bacteria.

While burping is a normal part of digestion, the smell of sulfur indicates that food is staying in the stomach or intestines longer than usual, allowing H2S gas to build up.

Why does Zepbound cause them?

Zepbound belongs to a class of drugs called GLP-1 and GIP receptor agonists. To help with weight loss, Zepbound slows down how quickly food moves out of your stomach and into your small intestine (gastric emptying). This helps you feel full for a longer time, so you eat less.

But when food sits in the stomach for an extended period, it begins to break down and ferment. This process releases H2S gas, which eventually escapes as a sulfur-smelling burp.

How can I avoid sulfur burps?

You might not be able to avoid or get rid of sulfur burps completely, but they tend to be more common at these times during your Zepbound weight loss treatment:

• when you first start using Zepbound
• when your Zepbound dosage is increased

For most people, Zepbound sulfur burps occur less frequently and become less bothersome as the digestive system adapts to the medication over time.

Medical Perspective

Certain foods can increase the probability of developing side effects from GLP-1 medications. For example, you may experience worsened nausea or bloating when you eat fried food or fast food.

— Alex Nguyen, PharmD, RPh, CPh

Learn more about digestive and other side effects of Zepbound.

_{Quotes represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.}

Tips for managing Zepbound sulfur burps

Until then, here are some things you can do to reduce the H2S gas buildup in your stomach that causes Zepbound sulfur burps:

• Eat smaller meals: Instead of three large meals, try eating four to six smaller portions throughout the day. This prevents the stomach from becoming too full, which reduces the amount of food sitting and fermenting.
• Stay hydrated: Drinking plenty of water helps your digestive system move more smoothly. It also helps prevent constipation, which can contribute to gas.
• Avoid “trigger” foods: Certain foods are high in sulfur and can make the smell worse. These include red meats, eggs, dairy, and vegetables like broccoli, cabbage, and Brussels sprouts.
• Limit high-fat foods: Fat takes longer to digest than protein or carbohydrates. Eating greasy or fried foods can slow down your digestion even further, making burps more likely.
• Avoid carbonated beverages: Soda and sparkling water add extra air to your stomach, which will eventually need to come out as a burp.
• Remain upright after eating: Avoid lying down for at least two to three hours after a meal to help gravity assist your digestion.

When to talk with your doctor

Sulfur burps are usually a harmless side effect of Zepbound. But a gassy stomach sometimes can be a sign of a more serious issue. Eli Lilly and Company, the manufacturer of Zepbound, advises patients to contact their healthcare professional if they experience “severe stomach problems.”

Seek medical advice if your Zepbound sulfur burps are accompanied by:

• severe or persistent vomiting or diarrhea
• intense pain in the upper stomach area that may spread to your back (a possible sign of pancreatitis)
• signs and symptoms of dehydration, such as dark urine or extreme thirst
• fever or yellowing of the skin or eyes (jaundice)

Summary

Sulfur burps are a smelly but harmless side effect of Zepbound caused by how the medication slows down digestion. Adjusting your diet and eating smaller meals often can help reduce sulfur burps as your body gets used to Zepbound treatment.

Always keep your doctor informed about any side effects of Zepbound you are experiencing so they can help you manage your weight loss journey safely and comfortably.