Key takeaways
- Ozempic prefilled pens have built-in dose counters and windows that show when your pen is empty or how many doses are left.
- Your first pen may contain up to six doses. After this, each pen will typically contain four doses.
- If your pen does not contain enough medication for a full dose as prescribed, safely discard it and start a new pen.
Ozempic (semaglutide) is a prescription medication for certain people with type 2 diabetes. Doctors may also prescribe it off-label for weight loss or management.
You inject liquid Ozempic under the skin using a prefilled disposable pen. The pen has a counter and a window to show how many doses are left.
This article discusses how many doses are in an Ozempic pen and how to know if it is empty. It also discusses what to do if an Ozempic pen still looks full and how to dispose of it.

You can use the dose counter on your Ozempic pen to see whether it is empty or has enough medication for your next dose. Turn the dose dial on the end of the pen until the counter stops. What you see on the counter will depend on which color pen your doctor prescribed:
- Red label pen (0.25 mg or 0.5 mg doses): If the counter stops at 0.25 or 0.5, you have enough medication for your dose. If the counter stops before reaching your dose, there is not enough medication left.
- Blue label pen (1 mg dose): If the counter stops at 1, you have a full dose left. If it stops before 1, there is not enough medication left.
- Yellow label pen (2 mg dose): If the counter stops at 2, you have a full dose left. If it stops before 2, there is not enough medication left.
If the dose counter stops before your full dose, you should not use the pen. You should safely throw it away and use a new pen instead.
Your doctor or pharmacist can demonstrate how to use the Ozempic pen when they prescribe it.
Typically, Ozempic pens are disposable and cannot be refilled.
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Usually, an Ozempic pen contains four doses, but your first pen can supply up to six doses.
When you start Ozempic, your doctor will prescribe a starting dose of 0.25 milligrams (mg) once weekly for 4 weeks. This small dose helps your body get used to the medication and does not affect your blood sugar levels.
After the first 4 weeks, your doctor will increase their dose to 0.5 mg once a week. If you still need more help managing your blood sugar, your doctor might increase the dose to 1 mg after you have been on 0.5 mg for at least 4 weeks.
If you need even more control after that, your doctor may increase the dose to a maximum of 2 mg once a week, but only after you have taken the 1 mg dose for at least 4 weeks.
Your first Ozempic pen will deliver four 0.25-mg doses, followed by two 0.5-mg doses. After this, you will get a new pen that holds exactly four doses of your prescribed amount.
After using an Ozempic pen for the first time, you can store it for 56 days in the following ways:
- at a controlled room temperature of 59°F to 86°F (15°C to 30°C)
- in a refrigerator at 36°F to 46°F (2°C to 8°C)
After 56 days or when the pen is empty, dispose of it using an approved sharps container, even if it still contains Ozempic.
Keep the following tips in mind to ensure safe use:
- Do not freeze Ozempic or use Ozempic that has been frozen.
- Only use an Ozempic pen if the medication in the pen window looks clear and colorless. If the medication in the window looks cloudy or contains particles, do not use the pen. Dispose of it safely.
- Do not use an Ozempic pen past its expiration date. If new, unused pens are kept in a refrigerator, you can use them until the expiration date on the label.
- Do not share an Ozempic pen with anyone, even if it has a new needle. Sharing pens can spread serious infections, even if the pen looks clean.
Medical Perspective“Here are a few practical strategies to make injections smoother, less intimidating, and more comfortable:
- Practice without medication: Use a demo pen or practice device to familiarize yourself with the feel and steps before your first real dose. (Ask your doctor about demo pens and practice devices.)
- Pair with a calming ritual: Listen to soothing music, chat with a friend, or do deep breathing before and during the injection.
- Sit, don’t stand: Sitting can help you feel more stable and relaxed, especially if you’re prone to lightheadedness.
- Pinch the skin: For subcutaneous injections, gently pinching a fold of skin can help ensure proper depth and reduce discomfort.”
Read more: How to administer Ozempic
Quotes represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.
Typically, Ozempic pens contain four doses. However, your first Ozempic pen will contain four 0.25-mg doses and two 0.5-mg doses.
Each pen is color-coded and labeled with the prescribed dose. You can use the pen counter and window to check that the pen has enough medication for the correct dose.
It is possible for a pen to contain leftover medication, but it may not have enough medication for a correct dose. In this case, you should use a new Ozempic pen.
It is important to store Ozempic pens according to the manufacturer’s guidelines.
Disclaimer: While Medical News Today strives for factual, comprehensive, and current information, this article is not a substitute for a licensed healthcare professional’s expertise. Always consult a doctor before taking or discontinuing any medication. Drug information is subject to change and may not cover all uses, directions, precautions, warnings, interactions, reactions, or adverse effects. The lack of a warning does not guarantee a drug’s safety, effectiveness, or appropriateness for all patients or specific uses. Learn more about our approach to content integrity.
