| Entry |
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| Name |
L-amino-acid oxidase;
ophio-amino-acid oxidase (ambiguous)
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| Class |
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
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| Sysname |
L-amino-acid:oxygen oxidoreductase (deaminating)
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| Reaction(IUBMB) |
an L-amino acid + H2O + O2 = a 2-oxo carboxylate + NH3 + H2O2 [RN: R01259]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A flavoprotein (FAD).
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| History |
EC 1.4.3.2 created 1961
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| Pathway |
| ec00250 | Alanine, aspartate and glutamate metabolism |
| ec00270 | Cysteine and methionine metabolism |
| ec00280 | Valine, leucine and isoleucine degradation |
| ec00400 | Phenylalanine, tyrosine and tryptophan biosynthesis |
| ec00950 | Isoquinoline alkaloid biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
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| Genes |
| CSAB: | 103225935 103235062(IL4I1) |
| PANU: | 101019624(IL4I1) 110742566 |
| RBB: | 108535617 108535810(IL4I1) |
| PCOQ: | 105809415(IL4I1) 105812258 |
| MMU: | 100328588(Il4i1b) 100470(Lao1) 14204(Il4i1) 73988(4930438A08Rik) |
| MCAL: | 110293665 110299207(Il4i1) 110304492 |
| MPAH: | 110323726 110324379(Il4i1) 110331259 |
| RNO: | 100360621(Il4i1) 287305(4930438A08Rikl) 298483(Lao1) |
| MCOC: | 116077959 116095759 116102147(Il4i1) |
| ANU: | 117703601(Il4i1) 117709387 117711952 |
| ASYL: | 127669744(Il4i1) 127680079 127693934 |
| MUN: | 110546799(Il4i1) 110547447 110547449 110547463 110552192 |
| CGE: | 100753207 100773063(Il4i1) 118237661 |
| MAUA: | 101827975(Il4i1) 101836430 101840413 |
| PROB: | 127213766(Il4i1) 127219242 127225078 |
| PLEU: | 114684326(Il4i1) 114686459 114704946 |
| MORG: | 121442718 121444808 121447825 121456358 121463608(Il4i1) |
| MFOT: | 126488192 126492502 126494328 126513079 |
| AAMP: | 119803103(Il4i1) 119804317 119811486 119817212 |
| NGI: | 103728550 103743345 103743685(Il4i1) |
| CPOC: | 100722053(Il4i1) 100735244 |
| CCAN: | 109678621 109683916(Il4i1) 109685329 |
| DORD: | 105985117 105985269 105986039 105994157(Il4i1) |
| DSP: | 122103786 122103787 122103789 122103841 122125580(Il4i1) |
| PLOP: | 125355664 125359440 125368104(Il4i1) |
| NCAR: | 124964052 124967124 124986519 |
| MMMA: | 107141477 107151225(Il4i1) 107159769 |
| ITI: | 101957942(Il4i1) 101974333 101978314 120885622 |
| OCU: | 100353438 100355677 103347204 |
| OPI: | 101528013(IL4I1) 101530470 |
| TUP: | 102481575 102484685(IL4I1) |
| GVR: | 103583510 103606222 103607899(IL4I1) |
| CFA: | 482436 484371(IL4I1) |
| CLUD: | 112642246 112645120(IL4I1) |
| VVP: | 112908249 112931512(IL4I1) |
| VLG: | 121478904(IL4I1) 121481065 |
| NPO: | 129500106(IL4I1) 129520896 |
| AML: | 100465325(IL4I1) 100476680 |
| UMR: | 103657267(IL4I1) 103670918 |
| UAH: | 113243274(IL4I1) 113254224 |
| UAR: | 123776239(IL4I1) 123793625 |
| MPUF: | 101679701 101682166(IL4I1) |
| MNP: | 132001676 132006123(IL4I1) |
| MLK: | 131809419 131818022(IL4I1) |
| NVS: | 122899845 122913870(IL4I1) |
| ORO: | 101367095(IL4I1) 101374427 |
| EJU: | 114199615(IL4I1) 114224205 |
| ZCA: | 113914518 113935944(IL4I1) |
| MLX: | 117998280(IL4I1) 118019531 |
| NSU: | 110572712(IL4I1) 110575253 |
| FCA: | 101100683(IL4I1) 111561629 |
| PYU: | 121017594 121018799(IL4I1) |
| PCOO: | 112850818(IL4I1) 112863418 |
| PBG: | 122479388 122493838(IL4I1) |
| PVIV: | 125153669(IL4I1) 125171765 |
| LRUF: | 124510891 124514368 |
| LGF: | 123578718(IL4I1) 123596785 |
| PTG: | 102958405(IL4I1) 107179172 |
| PPAD: | 109253035(IL4I1) 109254834 |
| PLEZ: | 122207689(IL4I1) 122225863 |
| HHV: | 120236036 120240706(IL4I1) |
| BOM: | 102265076(IL4I1) 102281829 |
| BIU: | 109556898 109572132(IL4I1) |
| BBUB: | 102390358 102390534(IL4I1) |
| BBIS: | 104995675(IL4I1) 105004981 |
| CHX: | 102183203 102186899(IL4I1) |
| OAS: | 101103614 105602079(IL4I1) |
| BTAX: | 128045761 128051007 128062953 |
| CSUM: | 138070554 138096857(IL4I1) |
| ODA: | 120856603 120872106(IL4I1) |
| CCAD: | 122420530(IL4I1) 122429212 |
| MREE: | 136151380 136161557(IL4I1) |
| MBEZ: | 129540891 129546518(IL4I1) |
| SSC: | 100522257(IL4I1) 100524382 100525099 |
| CFR: | 102508990 102515461(IL4I1) 102517966 |
| CBAI: | 105062771(IL4I1) 105064484 105072853 |
| CDK: | 105090941 105094151 105100234(IL4I1) |
| VPC: | 102525051(IL4I1) 102531830 116279810 |
| BACU: | 103000198(IL4I1) 103011548 |
| BMUS: | 118885416(IL4I1) 118892576 |
| LVE: | 103085233 103091507(IL4I1) |
| OOR: | 101272245 101278148(IL4I1) |
| LALB: | 132509908(IL4I1) 132516245 |
| DLE: | 111175407 111180588(IL4I1) |
| PCAD: | 102976825(IL4I1) 102988769 |
| PSIU: | 116744318(IL4I1) 116760484 |
| NASI: | 112399533 112415583(IL4I1) |
| ECB: | 100055246 100147151 100147304(IL4I1) |
| EPZ: | 103558296(IL4I1) 103563233 103567078 |
| EAI: | 106840130 106847809 123281322(IL4I1) |
| MMYO: | 118655360(IL4I1) 118675115 |
| MLF: | 102417897 102425741(IL4I1) |
| MDT: | 132216190(IL4I1) 132229771 |
| MYUM: | 139000097(IL4I1) 139002384 |
| PKL: | 118712191(IL4I1) 118723116 |
| EFUS: | 103294923 103297762(IL4I1) |
| MNA: | 107531789(IL4I1) 107544363 |
| AJM: | 119050609(IL4I1) 119052159 |
| PHAS: | 123830204(IL4I1) 123832082 |
| PPAM: | 129069478 129082948(IL4I1) |
| PALE: | 102888858 102897392(IL4I1) |
| PGIG: | 120607388 120615521(IL4I1) |
| PVP: | 105301784(IL4I1) 105304057 |
| RAY: | 107500425(IL4I1) 107508277 |
| TOD: | 119236741 119249626(IL4I1) |
| LAV: | 100657023 100665294(IL4I1) 100677374 |
| TMU: | 101342469 101351869 101357695 |
| ETF: | 101660188 101663616 123522011(IL4I1) |
| DNM: | 101416894 101417025 101424791 101425232 101425498 101435175 101435655 101445014 101445089 111760677 |
| MDO: | 100010068 100032718 103099142(IL4I1) |
| SHR: | 100917854 100918118 100923259 100932442 116422917(IL4I1) |
| AFZ: | 127555560 127555562 127556598 127560775 |
| PCW: | 110194214 110205983 110219789(IL4I1) |
| TVP: | 118835483 118836277(IL4I1) 118836462 118857902 |
| PBRV: | 138146167 138146177 138152659 138173322(IL4I1) |
| PGUU: | 104463619(IL4I1) 104464838 |
| ASN: | 102368180 102384151 102384392 |
| AMJ: | 102565465 102573609(IL4I1) |
| PSS: | 102454164 102456958 102457207 102457453 102458451 102461938 |
| CMY: | 102942718 102945232 102945460 102945689 102945918 102947871 |
| CCAY: | 125621481 125621772 125621792 125621793 125629566 |
| DCC: | 119842483 119842484 119843047 119843050 |
| CPIC: | 101935439 101941085 101942263 101942815 101943090 101944444 |
| TST: | 117887160 117887178 117887179 117887181 117887215 |
| CABI: | 116819430 116820392 116820393 116820394 |
| MRV: | 120383048 120383050 120383102 120383683 120392389 120394231 |
| ACS: | 100563852 100566795 100566990 100567189 |
| ASAO: | 132765102 132765119 132765120 132765121 132766725 |
| PVT: | 110071372 110088018 110088019 110088021 110088022 |
| SUND: | 121918314 121920299 121920300 121920301 121920302 121920303 |
| PBI: | 103050915 103053826 103058185 |
| PMUR: | 107289616 107289625 107289632 107292853 |
| CTIG: | 120315924 120315945 120315946 120315948 |
| TSR: | 106539221 106544367 106555017 |
| PGUT: | 117668040 117668047 132709705 132709709 132709710 132711491 |
| APRI: | 131190293 131190406 131190410 131191202 |
| PTEX: | 113449660 113453618 |
| NSS: | 113422237 113424979 113428977 113430285 |
| VKO: | 123034405 123034410 123034411 123034607 |
| PMUA: | 114588443 114588610 114588621 114590937 |
| PRAF: | 128408725 128408894 128408900 128408905 |
| ZVI: | 118080102 118080932 118080933 |
| HCG: | 128343970 128343971 128343972 128343973 128344479 |
| EMC: | 129327468 129327681 129327696 129327697 129327698 129328350 129328515 129328976 129329228 |
| XLA: | 108696562 108696644(il4i1.L) |
| XTR: | 100493881(il4i1) 100496394 |
| NPR: | 108791768 108791770 108791771 |
| RTEM: | 120915363 120915364 120915365 120915366 |
| ACAT: | 141110996 141110997 141110998 |
| BBUF: | 120997974 120997986 |
| BGAR: | 122928754 122928755 |
| SANH: | 107657246 107670951 |
| CCAR: | 109064604 109103696(il4i1) |
| CAUA: | 113058421 113115537 |
| CGIB: | 127972193 128029454 |
| MASI: | 127421781 127429679 |
| CGAR: | 128532807 128532809 |
| NGRA: | 132901438 132901439 132901440 |
| AMEX: | 103030984 103034230 |
| CMAO: | 118827307 118827317 |
| CHAR: | 105893732(il4i1) 105899129 |
| SPIL: | 134065634(il4i1) 134074479 134078134 134078142 134078149 134102447 |
| TRU: | 101072153 101072660(il4i1) |
| TFS: | 130523058 130535153(il4i1) |
| TNG: | GSTEN00004026G001 GSTEN00026846G001 |
| LCO: | 104937478 104937491 104940603(il4i1) |
| TBEN: | 117468930(il4i1) 117469869 117486838 |
| CGOB: | 115017826(il4i1) 115024066 |
| PGEO: | 117457196 117457681 117457780 117463406 117463574 117463579 117463583 |
| GACU: | 117538261 117550024 117562130(il4i1) 117562636 |
| EMAC: | 134876173 134880582(il4i1) |
| ELY: | 117246507 117246508 117252548 117260093(il4i1) |
| EFO: | 125883491 125883492 125888255(il4i1) 125890786 |
| PLEP: | 121943552(il4i1) 121944726 121962097 121962098 121962508 121962509 |
| SLUC: | 116038885(il4i1) 116052105 116052106 116052108 116052109 116052146 |
| ECRA: | 117942447(il4i1) 117962121 117962122 |
| ESP: | 116680441 116695345 116695346 116695347 |
| PFLV: | 114545909 114545953 114546186 114546189 114546190 114546191 114552578(il4i1) |
| GAT: | 120814801(il4i1) 120823029 |
| PPUG: | 119209117(il4i1) 119222932 |
| AFB: | 129093284 129093496 129094755(il4i1) |
| CANA: | 137790801(il4i1) 137792538 137792539 |
| CVE: | 137868772(il4i1) 137874860 137874861 137874862 |
| MSAM: | 119882627(il4i1) 119896366 119912615 119912745 119918947 119918948 |
| SCHU: | 122870147 122870148 122879528(il4i1) |
| CUD: | 121504363 121504400 121504402 121504874 121505065 121505066 121527143(il4i1) |
| SPUL: | 138600734 138601076 138604670(il4i1) |
| LMIX: | 132978274 132980103(il4i1) |
| ALAT: | 119011603(il4i1) 119026630 119026646 |
| MZE: | 101470741 101473683 101473989 112431521 112431528 |
| ONL: | 100695605 100697201 100703044 100703315 100707943 |
| OAU: | 116311629 116311630 116312996(il4i1) 116313896 116331917 116333564 |
| OLA: | 101160780 101161073 101163441 101171229 105356325 |
| OML: | 112149798(il4i1) 112155644 112155698 112156072 112156354 112156355 |
| CSAI: | 133420292 133420404 133420938 133420939 133442223(il4i1) |
| XMA: | 102218509 102227815 102228075 106700049 |
| XCO: | 114149637 114156799 114156839 114157965 |
| XHE: | 116708192 116732114 116732163 116732189 |
| PRET: | 103461196 103474367 103480925 103480937 103480938 |
| PFOR: | 103149034 103149035 103149095 103149096 103156786 103156791 |
| PLAI: | 106935008 106947289 106947294 106947295 |
| PMEI: | 106908903 106911400 106926808 106926809 106926813 106926815 |
| GAF: | 122820715 122820716 122820989 122820990 122833314(il4i1) |
| PPRL: | 129351402 129355706(il4i1) 129376638 |
| CVG: | 107082273 107099630 107099631 107099633 107099634 107099636 107103271 |
| CTUL: | 119777187 119777189 119777195 119791854(il4i1) |
| GMU: | 124880954 124881157 124881159 124881160 124881161 124881168 124883694(il4i1) |
| NFU: | 107374444 107374445 107380798(il4i1) |
| KMR: | 108247696(il4i1) 108248303 108248304 |
| ALIM: | 106522793 106525020 106525021 106535079 |
| AOCE: | 111571215 111571474(il4i1) 111585379 |
| EJA: | 138196868(il4i1) 138214197 |
| BFRE: | 138632471(il4i1) 138636548 |
| MCEP: | 125009163 125013589(il4i1) 125024027 125024064 |
| SSEN: | 122766864 122773264(il4i1) |
| SSOE: | 131456808 131462881(il4i1) |
| HHIP: | 117752108 117752109 117752194 117772864(il4i1) |
| HSP: | 118102865 118102964 118102969 118106035(il4i1) |
| PPLT: | 128430057 128430058 128430059 128430061 128430522 128439603(il4i1) |
| SMAU: | 118284255 118298989(il4i1) 118316658 118316660 |
| LCF: | 108900578(il4i1) 108902378 108902379 |
| SDU: | 111234776(il4i1) 111236665 111236666 |
| SLAL: | 111652095 111652096 111671319(il4i1) |
| XGL: | 120792272(il4i1) 120797257 |
| BSPL: | 114851219 114851323 114868580(il4i1) |
| SJO: | 128360557(il4i1) 128383623 128384080 128384086 |
| SSCO: | 133980904(il4i1) 134005891 134005963 134006291 |
| GMH: | 115529244 115529245 115529407 115529412 115529413 115529414 115529430 115561419 |
| SASA: | 106561133 106580948 106612549 |
| STRU: | 115163246 115197037 115206184 |
| OMY: | 110492681 110503766(il4i1) 110507168 |
| OMM: | 135509573 135546306(il4i1) |
| OCLA: | 139381449 139382936 139385562 |
| SALP: | 111949891 111959920 111962163 |
| SNH: | 120018275 120029032(il4i1) 120066129 |
| CCLU: | 121532047 121565117 121567622 |
| LOC: | 102691176 102696231 102698727 |
| PSPA: | 121303996(il4i1) 121324337 |
| ARUT: | 117397171 117397368 117422133 117422222 |
| PSEX: | 120535817(il4i1) 120536710 |
| LCM: | 102345877 102355982 102367420 |
| AFIL: | 140141445 140142288 140142289 140156317 140156318 140156933 140163972 |
| HRF: | 124110692 124110693 124110715 124110716 124110823 124110824 124113997 124113999 124114004 124116185 124132876 124149366 124151981 124152001 |
| HRJ: | 124262556 124276867 124281648 124288113 124288116 124291771 124291796 |
| HASI: | 137256531 137283494 137284292 137284991 137285151 |
| HCRA: | 139457778 139464615 139465054 139468855 139469362 139469689 |
| CVN: | 111106941 111108980 111110105 |
| OED: | 125650797 125651195 125652609 |
| PMAX: | 117321607 117340737 |
| MMER: | 123527946 123528636 123528870 123528990 123529239 123530170 123530240 123536688 123540459 123543766 123551352 123551752 123551772 123553585 123553597 123553611 |
| RPHI: | 132732968 132739731 |
| DPOL: | 127841634 127869074 127870092 |
| MAEA: | 128207883 128207884 128208308 128210400 128218780 128219641 128219642 128220634 128224529 |
| LJP: | 135465988 135478017 135478052 |
| MCAZ: | 138039854 138041126 |
| MFOO: | 138005991 138006229 |
| XEN: | 124439720 124445263 124454201 124454202 124454222 124454577 124454760 124455753 124456649 |
| BSON: | S101395_02976(aofH) |
| BSTR: | QI003_10200 QI003_13630 |
| BAH: | BAMEG_2568 BAMEG_2666 |
| BAX: | H9401_1822 H9401_1917 |
| BANT: | A16_19620 A16_20580 |
| BANR: | A16R_19840 A16R_20850 |
| BANS: | BAPAT_1838 BAPAT_1931 |
| BANH: | HYU01_09650 HYU01_10105 |
| BAL: | BACI_c19070 BACI_c19910 |
| BCZ: | BCE33L1742 BCE33L1830 |
| BCR: | BCAH187_A2029 BCAH187_A2131 |
| BCB: | BCB4264_A1928 BCB4264_A2020 |
| BCU: | BCAH820_1960 BCAH820_2053 |
| BCG: | BCG9842_B3289 BCG9842_B3414 |
| BCER: | BCK_24490 BCK_24920 |
| BTK: | BT9727_1764 BT9727_1846 |
| BTB: | BMB171_C1713 BMB171_C1799 |
| BTHR: | YBT1520_10410 YBT1520_10910 |
| BTHI: | BTK_10555 BTK_11050 |
| BTC: | CT43_CH1876 CT43_CH1971 |
| BTF: | YBT020_09990 YBT020_10535 |
| BTG: | BTB_c19930(yobN1) BTB_c20850(yobN2) |
| BTN: | BTF1_07005 BTF1_07470 |
| BTHT: | H175_ch1902 H175_ch1997 |
| BTHU: | YBT1518_10725 YBT1518_11220 |
| BTHY: | AQ980_20055 AQ980_20560 |
| BWE: | BcerKBAB4_1799 BcerKBAB4_1880 |
| BWW: | bwei_2998 bwei_3087(yobN) |
| BMYO: | BG05_3969 BG05_4060 |
| BTY: | Btoyo_4504 Btoyo_4587 |
| BBY: | CY96_08710 CY96_09165 |
| BWD: | CT694_10540 CT694_11000 |
| BTRO: | FJR70_02055 FJR70_09500 |
| BMOB: | MLA2C4_09775 MLA2C4_10280 |
| BNT: | GSN03_09425 GSN03_09860 |
| BPAC: | LMD38_16465 LMD38_17040 |
| BPAN: | NLJ82_09525 NLJ82_10020 |
| BALU: | QRY64_11750 QRY64_12210 |
| BARD: | QRY57_07475 QRY57_11315 |
| BASD: | LCG60_12540 LCG60_13015 |
| BON: | A361_16545 A361_17005 |
| PFRI: | L8956_01840 L8956_11895 |
| PARG: | PspKH34_13710(yobN) |
|
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| Reference |
1 |
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| Authors |
Meister A, Wellner D. |
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| Title |
Flavoprotein amino acid oxidase. |
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| Journal |
In: Boyer PD, Lardy H, Myrback K (eds). The Enzymes. 2nd ed. Vol. 7. New York: Academic Press; 1963. p. 609-648. |
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| Reference |
|
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| Authors |
WELLNER D, MEISTER A. |
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| Title |
Crystalline L-amino acid oxidase of Crotalus adamanteus. |
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| Journal |
J Biol Chem 235:2013-8 (1960) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.4.3.2 |
| ExPASy - ENZYME nomenclature database: | 1.4.3.2 |
| BRENDA, the Enzyme Database: | 1.4.3.2 |
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| LinkDB |
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