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Brain Defenders: How to Protect Your Brain for Life
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'A science-based, actionable blueprint to shift the brain from decline to repair.' ― Dr David Sinclair, New York Times bestselling author of Lifespan
'This is one of the most distinct and important conversations I've had about the future of your brain...thought-provoking and, above all, hopeful.' ― Dr Rangan Chatterjee, from his podcast Feel Better, Live More.
A ground-breaking new book from the bestselling author Dr David Perlmutter that will transform our understanding and treatment of degenerative brain diseases.
In recent years microglia cells housed in the brain have been identified as playing a key role in a host of neurodegenerative diseases such as Alzheimer's, Parkinson's, Long Covid, and MS amongst others. When operating optimally, these cells support healthy brain function. However, when they go rogue, they cause inflammation in the brain, contributing to cell death and devastating neurological conditions.
Current drug treatments mostly mask symptoms rather than cure and the statistics are grim: worldwide, 55 million people suffer from Alzheimer's, 10 million people have been diagnosed with Parkinson's, and serious neurological disorders are on a rapid rise.
And the good news? By following the lifestyle protocol that Dr David Perlmutter presents in the book people can become 'architects of their cognitive destiny'. The Brain Defenders program is accessible to all and will help us start to win the war against the scourge of neurodegenerative diseases.
- Print length384 pages
- LanguageEnglish
- PublisherYellow Kite
- Publication date27 Aug. 2026
- Dimensions15.2 x 3 x 23.2 cm
- ISBN-101399753339
- ISBN-13978-1399753333
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David Perlmutter consistently has his finger on the pulse of the newest and most important brain health research. ― Dr. Rudolph Tanzi, Professor of Neurology, Harvard Medical School, and New York Times bestselling author of Super Brain
Brain Defenders offers a powerful roadmap grounded in rigorous science and practical application. ― Dominic D’Agostino, PhD, Associate Professor, Department of Molecular Pharmacology and Physiology, USF Morsani College of Medicine
Brain Defenders is a landmark work that puts the power of prevention in your hands. ― Uma Naidoo, MD, nutritional psychiatrist, Harvard Medical School, and bestselling author of This Is Your Brain on Food
This book is a must read for anyone seeking a roadmap on how to shore up your brain's resilience against diseases of aging. ― William W. Li, MD, New York Times bestselling author of Eat to Beat Disease and Eat to Beat Your Diet
This book is an essential resource for clinicians and informed patients who want to shift from crisis response mode to proactive brain stewardship. ― Ben Greenfield, author of Boundless
Brain Defenders is an essential read for anyone seeking to enhance mental clarity, longevity, and overall brain wellness. ― Mark Sisson, founder of Primal Kitchen Foods and author of The Primal Blueprint
Brain Defenders offers a clear, accessible look at how metabolism, inflammation, and immune function influence brain health. ― Christopher Palmer, MD, assistant professor of psychiatry, Harvard Medical School, and author of Brain Energy
Brain Defenders reveals the breakthrough biology driving today's brain health crisis-and why this research is our best shot for the future of brain health. ― Austin Perlmutter, MD, coauthor of Brain Wash
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About the Author
Product details
- Publisher : Yellow Kite
- Publication date : 27 Aug. 2026
- Language : English
- Print length : 384 pages
- ISBN-10 : 1399753339
- ISBN-13 : 978-1399753333
- Item weight : 480 g
- Dimensions : 15.2 x 3 x 23.2 cm
- Best Sellers Rank: 13,483 in Books (See Top 100 in Books)
- 57 in Public Health & Preventive Medicine
- 115 in Popular Medicine
- 139 in General Medical Issues Guides
About the author

David Perlmutter, MD, FACN, ABIHM is a Board-Certified Neurologist, Fellow of the American College of Nutrition and six-time New York Times bestselling author. He received his M.D. degree from the University of Miami School of Medicine where he was awarded the Leonard G. Rowntree Research Award. Dr. Perlmutter is a frequent lecturer at symposia sponsored by such medical institutions as Columbia University, the University of Arizona, Scripps Institute, and Harvard University. He has contributed extensively to the world medical literature with publications appearing in The Journal of Neurosurgery, The Southern Medical Journal, Journal of Applied Nutrition, and Archives of Neurology. He is the author of the #1 New York Times Bestseller, Grain Brain. Other New York Times bestsellers include Brain Maker, The Grain Brain Cookbook, The Grain Brain Whole Life Plan and Brain Wash (January, 2020) co-written with his son, Austin Perlmutter, MD. He is recognized internationally as a leader in the field of nutritional influences in neurological disorders. Dr. Perlmutter has been interviewed on many nationally syndicated radio and television programs including 20/20, Larry King Live, CNN, Fox News, Fox and Friends, The Today Show, Oprah, and The CBS Early Show. In 2002 Dr. Perlmutter was the recipient of the Linus Pauling Award for his innovative approaches to neurological disorders and in addition was awarded the Denham Harmon Award for his pioneering work in the application of free radical science to clinical medicine. He is the recipient of the 2006 National Nutritional Foods Association Clinician of the Year Award. Most recently, Dr. Perlmutter was awarded the 2019 Global Leadership Award from the Integrative Healthcare Symposium. In December of 2017, Dr. Perlmutter lectured at the World Bank with his presentation broadcasted to 150 sites around the world. His books are now published in 36 languages. His latest work, New York Times bestseller, Drop Acid (February 15, 2022), explores how elevated uric acid powerfully threatens metabolic health, and how it can be brought under control. Dr. Perlmutter's next book, Brain Defenders - Harness the Power of Your Immune Cells to Protect Your Brain for Life (Avery / Penguin), will be published August, 2026 and available in The United States, China, Romania, Canada, Portugal, Spain, France, South Korea, Brazil, Germany, Croatia, Hungary, Poland, Italy and Great Britain.












