| Messenger RNA (mRNA) has immense therapeutic potential in infectious diseases and cancer immunotherapy. |
| Clinically successful lipid nanoparticles (LNPs) are smart nano-sized lipid-based carrier systems for mRNA delivery into the cytosol. |
| Engineering cationic ionizable lipids of LNPs with a suitable acid dissociation constant (pKa) for enhanced complexation and subsequent endosomal release is being actively researched. |
| There is a specific need to enhance the storage stability of LNP-mRNA vaccines to above 0 °C to bring these lifesaving vaccines to the developing world. |
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