Table 2.
Tumor-rejection antigens derived from non-canonical protein sequences.
| Epitope identifieda | Type of tumor | Origin of non-canonical peptide | Expression in normal tissue | Gene name | HLA restriction element | Reference |
|---|---|---|---|---|---|---|
| MSLQRQFLR | Melanoma | aORF | Unknown | TRP1 | HLA-A*31 | (69) |
| VYFFLPDHL | Melanoma | Intronic | Yes | GP100 | HLA-A*24 | (70) |
| RSDSGQQARY | Melanoma | Intronic | Yes/lowb | AIM2 | HLA-A*01 | (71) |
| VLPDVFIRC/VLPDVFIRCV | Melanoma | Intronic | No | GNTV | HLA-A*02:01 | (72) |
| EEKLIVVLF | Melanoma | Intronic | No | MUM1 | HLA-B*44:02 | (4) |
| LPAVVGLSPGEQEY | Renal cell carcinoma | aORF | Yes | MCSF | HLA-B*35:01 | (73) |
| SPRWWPTCL | Renal cell carcinoma | aORF | Yes/lowb | iCE | HLA-B*07:02 | (74) |
| EVISCKLIKR | Melanoma | Intronic | No | TRP2 | HLA-A*68:011/HLA-A*33:01 | (75) |
| LAAQERRVPR | Melanoma and breast cancer | aORF | Unknown | NYESO1 | HLA-A*31 | (76) |
| MLMAQEALAFL | Melanoma | aORF | Yes | LAGE1 | HLA-A*02:01 | (77) |
| CQWGRLWQL/MCQWGRLWQL | Melanoma | aORF | Unknown | BING4 | HLA-A*02 | (78) |
| LPRWPPPQL | Renal cell carcinoma | Intronic | Yes | RU2 | HLA-B*07 | (79) |
a
identified by cDNA library screens;
b
compared to cancer tissue; aORF, alternative open reading frame; HLA, human leukocyte antigen.