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. Author manuscript; available in PMC: 2019 Jun 24.
Published in final edited form as: Cancer Cell. 2015 Apr 2;27(4):561–573. doi: 10.1016/j.ccell.2015.02.014

Figure 3. mTRAIL-R promotes KRAS-driven pancreatic cancer progression and metastasis.

Figure 3

(A) Kaplan-Meier survival curve, Log-rank test ** p=0.004.

(B) Animals with metastasis in the liver and lungs as determined by H&E staining at time of death were quantified. Three of KPC-TRAIL-RWT/WT could not be determined due to tissue decay. Fisher’s exact test *** p >0.001 and * p > 0.05.

(C) Representative H&E stainings of pancreatic adenocarcinomas and lung tissues. Met=Metastasis; scale bar, 50 μm.

(D) Representative images of isotype, αPDX-1, αSp-C and αCC10 stainings of KPC lung metastases; scale bar, 25 μm.

(E) Representative images of αCC10 stainings of KP lung tumors; scale bar, 25 μm. See also Figure S2.