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. 2019 Mar 6;7:e6567. doi: 10.7717/peerj.6567

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© 2019 Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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Liraglutide increases miR-26a-5p to reduce PTEN thus increasing the levels of PIP3 to stimulate the PI3K-activated signaling cascades. In addition, liraglutide reduces miR-181a-5p and miR-34a-5p to increase the expression of Creb and Bcl-2, thus inhibiting the cell apoptosis. PTEN, phosphatase and tensin homologue on chromosome 10; PI3K, phosphoinositide 3-kinase; PIP2, phosphatidylinositol 4,5-bisphophate; PIP3, phosphatidylinositol (3,4,5)-trisphosphate; PDK, phosphoinositide-dependent kinase-1; Akt, serine/threonine kinase 1; Creb, cAMP responsive element binding protein; Sirt1, Sirtuin 1.