Table 3.
Adjusted IRRs and IRDs for MACE and Components of This Outcome
| Variable | PHEN/TPM |
Fixed-PHEN/TPM |
PHEN |
TPM |
||||
|---|---|---|---|---|---|---|---|---|
| Current Use | Unexposed (Reference) | Current Use | Unexposed (Reference) | Current Use | Unexposed (Reference) | Current Use | Unexposed (Reference) | |
| Person-years | 2820 | 232,470 | 2207 | 217,665 | 22,218 | 251,807 | 60,889 | 291,147 |
| MACE | ||||||||
| Events, n | 3 | 424 | 1 | 395 | 17 | 423 | 186 | 539 |
| IRR (95% CI) | 0.57 (0.19 to 1.78) | 0.24 (0.03 to 1.70) | 0.56 (0.34 to 0.91) | 1.58 (1.33 to 1.87) | ||||
| IRD (95% CI) | −0.79 (−2.03 to 0.44) | −1.43 (−2.37 to −0.50) | −0.62(−1.02 to −0.22) | 1.11 (0.64 to 1.57) | ||||
| AMI | ||||||||
| Events, n | 1 | 240 | 0 | 225 | 9 | 241 | 51 | 296 |
| IRR (95% CI) | 0.35 (0.05 to 2.52) | 0.00 (0.00 to NC) | 0.51 (0.26 to 1.00) | 0.79 (0.59 to 1.07) | ||||
| IRD (95% CI) | −0.66 (−1.37 to 0.06) | −1.02 (−1.20 to −0.85) | −0.39 (−0.68 to −0.10) | −0.22 (−0.48 to 0.04) | ||||
| Stroke | ||||||||
| Events, n | 2 | 167 | 1 | 154 | 7 | 167 | 133 | 217 |
| IRR (95% CI) | 0.89 (0.22 to 3.53) | 0.55 (0.08 to 3.85) | 0.58 (0.27 to 1.24) | 2.81 (2.26 to 3.50) | ||||
| IRD (95% CI) | −0.09 (−1.10 to 0.92) | −0.37 (−1.29 to 0.54) | −0.23 (−0.49 to 0.03) | 1.38 (1.01 to 1.76) | ||||
| CV-related death | ||||||||
| Events, n | 0 | 17 | 0 | 16 | 1 | 15 | 2 | 26 |
| IRR (95% CI) | 0.00 (0.00 to NC) | 0.00 (0.00 to NC) | 1.03 (0.12 to 8.67) | 0.35 (0.08 to 1.45) | ||||
| IRD (95% CI) | −0.04 (−0.07 to −0.02) | −0.04 (−0.06 to −0.02) | 0.00 (−0.09 to 0.09) | −0.06 (−0.12 to 0.00) | ||||
Data are adjusted for propensity score decile after trimming.
Abbreviation: NC, not calculated.