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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Immunol Rev. 2018 Jul;284(1):42–50. doi: 10.1111/imr.12661

Figure 3. Mathematical model for permissive selection in GCs.

Figure 3

The probability of a LZ GC B cell being selected for cell division is a function of its BCR avidity relative to its GC competitors. GC B cells whose BCRs surpass some avidity threshold (T) are guaranteed to divide, while those with the lowest-avidity BCRs have a small-but-non-zero probability of receiving selection signals. Adapted from (38).