Table 2.
Psychiatric outcomes in patients with obesity using GLP-1 RA.
| Cumulative probability of study event since index date | ||||||
|---|---|---|---|---|---|---|
| Study event | n of event | 6-months | 1-year | 3-years | 5-years | Hazard ratio (95% CI) |
| Any psychiatric diseases | ||||||
| GLP-1 RA | 36,789 | 9.36% | 15.29% | 29.62% | 39.64% | 1.98(1.94-2.01) |
| Non-GLP-1 RA | 27,349 | 4.76% | 7.63% | 16.45% | 23.38% | Reference |
| Major depressive disorder | ||||||
| GLP-1 RA | 6,085 | 1.41% | 2.38% | 4.99% | 7.02% | 2.95(2.82-3.08) |
| Non-GLP-1 RA | 2,952 | 0.36% | 0.66% | 1.67% | 2.68% | Reference |
| Anxiety | ||||||
| GLP-1 RA | 26,741 | 6.35% | 10.69% | 21.68% | 30.03% | 2.08(2.04-2.12) |
| Non-GLP-1 RA | 18,895 | 3.09% | 4.98% | 11.16% | 16.45% | Reference |
| Suicide ideations or attempts | ||||||
| GLP 1 RA | 1,901 | 0.22% | 0.42% | 1.45% | 3.64% | 2.06(1.92-2.21) |
| Non-GLP-1 RA | 1,559 | 0.21% | 0.35% | 0.89% | 1.42% | Reference |